FIGURE

Fig. 7

ID

ZDB-FIG-140512-6

Publication

Xu et al., 2014 - Gbeta1 controls collective cell migration by regulating the protrusive activity of leader cells in the posterior lateral line primordium

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Fig. 7

Gβ1 acts synergistically with Cxcr4b to regulate migration of the pLLP. (A-D) Epifluorescence images of the following 48-hpf Tg(-8.0cldnb:lynEGFP) embryos: WT uninjected control (A), cxcr4b^(+/-) (B), WT injected with a low dose of gnb1a/b MO1 (1 ng, C) and cxcr4b^(+/-) injected with a low dose of gnb1a/b MO1 (1 ng, D). Lateral views with anterior to the left; white arrowheads, NMs; and red arrows, posterior-most deposited NM. (F) Quantification of pLLP migration in embryos, as indicated in Fig. 2.

Expression Data

Gene:	EGFP
Fish:	zf106Tg cxcr4b^t26035/+; zf106Tg zf106Tg + MO2-gnb1a + MO2-gnb1b + MO4-tp53 cxcr4b^t26035/+; zf106Tg + MO2-gnb1a + MO2-gnb1b + MO4-tp53
Knockdown Reagents:	MO2-gnb1a MO2-gnb1b MO4-tp53
Anatomical Terms:	lateral line neuromast posterior lateral line primordium
Stage:	Long-pec

Expression Detail

Antibody Labeling

Phenotype Data

Fish:	zf106Tg + MO2-gnb1a + MO2-gnb1b + MO4-tp53 cxcr4b^t26035/+; zf106Tg + MO2-gnb1a + MO2-gnb1b + MO4-tp53
Knockdown Reagents:	MO2-gnb1a MO2-gnb1b MO4-tp53
Observed In:	posterior lateral line neuromast primordium migration
Stage:	Long-pec

Phenotype Detail

Acknowledgments

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Reprinted from Developmental Biology, 385(2), Xu, H., Ye, D., Behra, M., Burgess, S., Chen, S., and Lin, F., Gbeta1 controls collective cell migration by regulating the protrusive activity of leader cells in the posterior lateral line primordium, 316-27, Copyright (2014) with permission from Elsevier. Full text @ Dev. Biol.