FIGURE

Fig. 1

ID

ZDB-FIG-140507-6

Publication

Fero et al., 2014 - Impaired embryonic motility in dusp27 mutants reveals a developmental defect in myofibril structure

Other Figures

All Figure Page

Back to All Figure Page

Fig. 1

Embryonic motility is impaired in y241 mutant embryos. (A) Swimming response to a tactile stimulus is severely impaired in 2 dpf y241 mutants. Image frames are at 10 ms intervals from a touch stimulus delivered with a fine needle. Siblings (top panels) swim rapidly forward, whereas mutants (lower panels) respond with a barely perceptible shiver. (B) y241 mutants (bottom panel) show edema adjacent to the heart (asterisk), tail curvature (arrowhead) and smaller eyes. Scale bar: 300 μm. (C) Curvature trace for 120 ms during an acoustic startle response in a sibling (black) and y241 mutant (red) embryo. The stimulus was delivered at 30 ms (arrow). (D) The magnitude of the initial C-bend in y241 mutant acoustic startle responses is reduced compared with that of wild-type embryos (n=6 larvae each), whereas (E) the duration of the initial C-bend is not significantly different. *P<0.001. (F) Spontaneous coiling is strongly reduced in y241 mutants (gray, n=7) compared with wild-type siblings (black, n=37) during the entire period of early locomotor development. y-axis is arbitrary units. Inset, average coiling during 24–28 hpf for the same larvae. *P<0.001. Graphs show mean ± s.e.m.

Expression Data

Expression Detail

Antibody Labeling

Phenotype Data

Fish:	dusp27^{y241Et/y241Et} (TL)
Observed In:	eye heart musculoskeletal movement post-vent region
Stage:	Long-pec

Phenotype Detail

Acknowledgments

This image is the copyrighted work of the attributed author or publisher, and ZFIN has permission only to display this image to its users. Additional permissions should be obtained from the applicable author or publisher of the image. Full text @ Dis. Model. Mech.