FIGURE

Fig. S3

ID

ZDB-FIG-140403-8

Publication

Cox et al., 2014 - S-Nitrosothiol Signaling Regulates Liver Development and Improves Outcome following Toxic Liver Injury

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Fig. S3

NO signaling regulates liver size in a cGMP-independent manner involving modulation of S-nitrosothiol homeostasis.

(A) GSNOR (alcohol dehydrogenase 5, Type III) is highly conserved among vertebrates (Red = Conserved residues, Blue = Non-conserved residues). (B) Effect of GSNOR inhibition (1 μM) on liver size in Tg(lfabp:GFP) embryos. Representative fluorescent photomicrographs were taken at 10x magnification. (C) Phenotypic analysis of liver size in embryos treated with different doses of GSNORi as determined by in situ hybridization for lfabp in treated embryos at 72 hpf (S=small, M=medium, L=large, N>50 embryos/treatment). (D) Effect of GSNOR inhibition (1 μM) on hepatic progenitors as determined by in situ hybridization for sid4 at 48 hpf.

Expression Data

Expression Detail

Antibody Labeling

Phenotype Data

Phenotype Detail

Acknowledgments

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