ZFIN Image: Cox et al., 2014, Fig. S3

Image

Figure Caption

Fig. S3

NO signaling regulates liver size in a cGMP-independent manner involving modulation of S-nitrosothiol homeostasis.

(A) GSNOR (alcohol dehydrogenase 5, Type III) is highly conserved among vertebrates (Red = Conserved residues, Blue = Non-conserved residues). (B) Effect of GSNOR inhibition (1 μM) on liver size in Tg(lfabp:GFP) embryos. Representative fluorescent photomicrographs were taken at 10x magnification. (C) Phenotypic analysis of liver size in embryos treated with different doses of GSNORi as determined by in situ hybridization for lfabp in treated embryos at 72 hpf (S=small, M=medium, L=large, N>50 embryos/treatment). (D) Effect of GSNOR inhibition (1 μM) on hepatic progenitors as determined by in situ hybridization for sid4 at 48 hpf.

Acknowledgments

This image is the copyrighted work of the attributed author or publisher, and ZFIN has permission only to display this image to its users. Additional permissions should be obtained from the applicable author or publisher of the image. Full text @ Cell Rep.