FIGURE

Fig. 1

ID

ZDB-FIG-140304-24

Publication

He et al., 2014 - Maternal control of axial-paraxial mesoderm patterning via direct transcriptional repression in zebrafish

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Fig. 1

Maternal Vsx1 is essential for axial–paraxial mesoderm patterning in zebrafish. (A–C) Uninjected wild-type control embryos. (D–F) vsx1 tbMO injected embryos exhibit dorsalized phenotype with disturbed dorsal midline structure. (G–I) vsx1 overexpression elicits inhibition of axial mesoderm specification and aberrant convergence of specified paraxial mesoderm. (J–L) Injection of vsx1 sbMO has no detectable effect on development before 24 hpf. Phenotypes are shown at 24 hpf. (M) Proportion of different phenotypes in vsx1 knockdown, overexpression and rescue experiments at 24 hpf. DDMS: disorganized dorsal midline structure. SB: spina bifida.

Expression Data

Expression Detail

Antibody Labeling

Phenotype Data

Fish:	WT + MO1-vsx1 WT + MO2-vsx1
Knockdown Reagents:	MO1-vsx1 MO2-vsx1
Observed In:	anatomical structure dorso-medial region somite spinal cord whole organism
Stage:	Prim-5

Phenotype Detail

Acknowledgments

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Reprinted from Developmental Biology, 386(1), He, Y., Xu, X., Zhao, S., Ma, S., Sun, L., Liu, Z., and Luo, C., Maternal control of axial-paraxial mesoderm patterning via direct transcriptional repression in zebrafish, 96-110, Copyright (2014) with permission from Elsevier. Full text @ Dev. Biol.