FIGURE

Fig. 3

ID

ZDB-FIG-140214-40

Publication

Valvezan et al., 2014 - Oncogenic mutations in Adenomatous Polyposis Coli (Apc) activate mechanistic Target of Rapamycin Complex 1 (mTORC1)

Other Figures

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Fig. 3

mTORC1 inhibition improves circulation in apc^mcr/mcr zebrafish. (A) apc^mcr/mcr zebrafish were treated with vehicle or Torin1 (250 nM) and the rate of blood flow through the dorsal aorta was measured using high speed videomicroscopy in unanesthetized larvae at 2-3 dpf. Blood flow phenotypes were categorized according to flow rate as indicated. Representative movies for each scoring category can be found in online supplementary material (supplementary material Movies 1-4). (B) Rapamycin also improved circulation in apc^mcr/mcr zebrafish. (C,D) Torin1 and rapamycin treatment did not increase the heart rate of apc^mcr/mcr zebrafish.

Expression Data

Expression Detail

Antibody Labeling

Phenotype Data

Fish:	apc^hu745/hu745
Observed In:	dorsal aorta blood dorsal aorta blood circulation
Stage Range:	Long-pec to Protruding-mouth

Phenotype Detail

Acknowledgments

This image is the copyrighted work of the attributed author or publisher, and ZFIN has permission only to display this image to its users. Additional permissions should be obtained from the applicable author or publisher of the image. Full text @ Dis. Model. Mech.