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Publication: Valvezan et al., 2014 - Oncogenic mutations in Adenomatous Polyposis Coli (Apc) activate mechanistic Target of Rapamycin Complex 1 (mTORC1)
All Figures: Figures for Valvezan et al., 2014

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Fig. 3

mTORC1 inhibition improves circulation in apc^mcr/mcr zebrafish. (A) apc^mcr/mcr zebrafish were treated with vehicle or Torin1 (250 nM) and the rate of blood flow through the dorsal aorta was measured using high speed videomicroscopy in unanesthetized larvae at 2-3 dpf. Blood flow phenotypes were categorized according to flow rate as indicated. Representative movies for each scoring category can be found in online supplementary material (supplementary material Movies 1-4). (B) Rapamycin also improved circulation in apc^mcr/mcr zebrafish. (C,D) Torin1 and rapamycin treatment did not increase the heart rate of apc^mcr/mcr zebrafish.

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