FIGURE

Fig. 4

ID

ZDB-FIG-140122-5

Publication

Hayes et al., 2013 - Spinal Deformity in Aged Zebrafish Is Accompanied by Degenerative Changes to Their Vertebrae that Resemble Osteoarthritis

Other Figures

All Figure Page

Back to All Figure Page

Fig. 4

The vertebral cartilage of aging fish is rich in chondroitin, but not keratan, sulfate.

A-B. Immunohistochemical labelling controls showing no non-specific binding of primary (mIg, ‘naive’ mouse immunoglobulin) or secondary antibody (PBS, phosphate buffered saline). C-N. Immunohistochemical labelling patterns of chondroitin/dermatan (C-0-S, C-4-S/DS, C-6-S) and keratan sulfate (KS) at 1, 2 and 3 years (left, middle and right panels, respectively). Note prominent pericellular labelling of CS/DS epitopes, particularly in 2 and 3 year samples. Unlike CS, KS occurs only within the notochordal tissue of the intervertebral disc (bottom left; arrowhead) and appears to diminish during aging. Scalebar represents 100 microns.

Expression Data

Expression Detail

Antibody Labeling

Phenotype Data

Phenotype Detail

Acknowledgments

This image is the copyrighted work of the attributed author or publisher, and ZFIN has permission only to display this image to its users. Additional permissions should be obtained from the applicable author or publisher of the image. Full text @ PLoS One