FIGURE

Fig. 6

ID

ZDB-FIG-131015-19

Publication

Shih et al., 2013 - Aromatic L-Amino Acid Decarboxylase (AADC) Is Crucial for Brain Development and Motor Functions

Other Figures

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Fig. 6

Morphological changes in DA neuron patterning.

In situ hybridization with tyrosine hydroxylase anti-sense mRNA probe. (A) Control. (B) 5 ng ddc tMO1 treated. (C) 100 pg ddc mRNA treated. (D) Co-injected mixture with 5 ng ddc tMO1 and 50 pg ddc mRNA with non-tMO1 binding site. Numbers show the site of dopaminergic neuron clusters 1-7 and 8, which indicated spots in retina, locus coeruleus (LC), pre-tectum (PrC, arrowhead) and olfactory bulb (OB, arrow). Compared to tyrosine hydroxylase expression pattern in control larvae, several tissue parties including olfactory bulb, pre-tectum and DA cluster were malpositioned or absent in the ddc morphant brains.

Expression Data

Gene:	th
Fish:	AB/TU AB/TU + MO1-ddc
Knockdown Reagent:	MO1-ddc
Anatomical Terms:	diencephalon dopaminergic neuron locus coeruleus dopaminergic neuron olfactory bulb dopaminergic neuron pretectum dopaminergic neuron
Stage:	Protruding-mouth

Expression Detail

Antibody Labeling

Phenotype Data

Fish:	AB/TU + MO1-ddc
Knockdown Reagent:	MO1-ddc
Observed In:	diencephalon dopaminergic neuron dopaminergic neuron
Stage:	Protruding-mouth

Phenotype Detail

Acknowledgments

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