FIGURE

Fig. 1

ID

ZDB-FIG-130909-10

Publication

Kim et al., 2013 - Heterozygous inactivation of tsc2 enhances tumorigenesis in p53 mutant zebrafish

Other Figures

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Fig. 1

mTORC1 signaling in malignant abdominal tumors in p53^zdf1/zdf1 zebrafish. (A) 1-year-old p53^zdf1/zdf1 mutant fish with prominent abdominal tumor. (B) Hematoxylin and eosin (H&E) staining of a section from an abdominal tumor showing whorls of spindle-shaped cells consistent with an invasive sarcoma. (C,D) Increased expression of mTORC1 downstream effectors phospho-S6 (C) and phospho-4EBP1 (D) in abdominal tumors from p53^zdf1/zdf1 zebrafish. For C and D, red fluorescence is immunosignal and blue is DAPI nuclear stain. M, muscle; T, tumor. Scale bars: 100 μm. Similar findings were seen in abdominal tumors from 10/10 p53^zdf1/zdf1 zebrafish.

Expression Data

Antibodies:	Ab1-eif4ebp1 Ab1-rps6
Fish:	tp53^zdf1/zdf1
Anatomical Term:	trunk sarcoma
Stage:	Adult

Expression Detail

Antibody Labeling

Phenotype Data

Fish:	tp53^zdf1/zdf1
Observed In:	trunk sarcoma
Stage:	Adult

Phenotype Detail

Acknowledgments

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