IMAGE

Fig. 1

ID

ZDB-IMAGE-130909-10

Antibodies

Publication

Kim et al., 2013 - Heterozygous inactivation of tsc2 enhances tumorigenesis in p53 mutant zebrafish

All Figures

Figures for Kim et al., 2013

Image

Figure Caption

Fig. 1

mTORC1 signaling in malignant abdominal tumors in p53^zdf1/zdf1 zebrafish. (A) 1-year-old p53^zdf1/zdf1 mutant fish with prominent abdominal tumor. (B) Hematoxylin and eosin (H&E) staining of a section from an abdominal tumor showing whorls of spindle-shaped cells consistent with an invasive sarcoma. (C,D) Increased expression of mTORC1 downstream effectors phospho-S6 (C) and phospho-4EBP1 (D) in abdominal tumors from p53^zdf1/zdf1 zebrafish. For C and D, red fluorescence is immunosignal and blue is DAPI nuclear stain. M, muscle; T, tumor. Scale bars: 100 μm. Similar findings were seen in abdominal tumors from 10/10 p53^zdf1/zdf1 zebrafish.

Figure Data

Expression / Labeling details

Phenotype details

Acknowledgments

This image is the copyrighted work of the attributed author or publisher, and ZFIN has permission only to display this image to its users. Additional permissions should be obtained from the applicable author or publisher of the image. Full text @ Dis. Model. Mech.