FIGURE

Fig. 3

ID

ZDB-FIG-130826-51

Publication

Chapman et al., 2013 - Axonal Transport Defects in a Mitofusin 2 Loss of Function Model of Charcot-Marie-Tooth Disease in Zebrafish

Other Figures

All Figure Page

Back to All Figure Page

Fig. 3

MFN2L285X/L285X zebrafish have a progressive swimming defect.

(A) Kaplan-Meier plot of swimming endurance in 100 and 200 day-old zebrafish of each genotype. MFN2+/+ and MFN2^L285X/+ zebrafish swam for 30 minutes at both 100 and 200d old. For clarity only the 200d data is plotted, although the lines are superimposed. (MFN2^L285X/L285X: p<0.001 at both ages, Log-rank (Mantel-Cox) test). (B) Frequency distribution plot of swimming angle (measured from horizontal) of adult wild type zebrafish. Representative frames captured from digital video recordings of adult zebrafish and cartoons are shown. The upper panel shows a wild type sibling, and the lower panel shows a MFN2^L285X/L285X zebrafish showing abnormal posture, with the body angled at 30° from horizontal. (C) Bar graph showing the percentage of time spent with normal swimming posture during 1 minute of observation in 90 day-old zebrafish (p<0.0001, 2-sided T test Mann-Whitney). (D) Bar graph showing the mean duration of each bout of abnormal swimming in 90 day-old old zebrafish (p<0.0001, 2-sided T test Mann-Whitney). (E, F) Graphs showing the decline in normal swimming posture (E) and the increasing duration of each bout of abnormal swimming (F), between 105 and 155 days old.

Expression Data

Expression Detail

Antibody Labeling

Phenotype Data

Fish:	mfn2^{hu3528/hu3528}
Observed In:	swimming whole organism
Stage:	Adult

Phenotype Detail

Acknowledgments

This image is the copyrighted work of the attributed author or publisher, and ZFIN has permission only to display this image to its users. Additional permissions should be obtained from the applicable author or publisher of the image. Full text @ PLoS One