FIGURE

Fig. 7

ID

ZDB-FIG-130507-6

Publication

Grisham et al., 2013 - Mutations in ap1b1 Cause Mistargeting of the Na(+)/K(+)-ATPase Pump in Sensory Hair Cells

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Fig. 7

Increase of intracellular Na⁺ levels in mutant HCs.

A?C, Sodium Green label in WT, tm246a and t20325 mutant neuromasts. Dotted magenta circles outline HCs that were used for quantification in that plane of view. Scale bar, 5 µm. D, Quantification of Sodium Green label in ap1b1 mutant, pcdh15^th263b, and corresponding WT HCs. (tm246a: WT n = 124, mutant n = 90; t20325: WT n = 125, mutant n = 74; th263b: WT n = 100, mutant n = 84 HCs). Error bars represent SEM. Statistical analysis performed with a Mann-Whitney U-test.

Expression Data

Expression Detail

Antibody Labeling

Phenotype Data

Fish:	ap1b1^{t20325/t20325} ap1b1^{tm246a/tm246a} pcdh15a^{th263b/th263b}
Observed In:	intracellular sodium ion homeostasis neuromast hair cell
Stage:	Day 5

Phenotype Detail

Acknowledgments

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