FIGURE

Fig. 2

ID

ZDB-FIG-130418-9

Publication

Amemiya et al., 2013 - The African coelacanth genome provides insights into tetrapod evolution

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Fig. 2

a, Organization of the mouse HOX-D locus and centromeric gene desert, flanked by the Atf2 and Mtx2 genes. Limb regulatory sequences (I1, I2, I3, I4, CsB and CsC) are noted. Using the mouse locus as a reference (NCBI and mouse genome sequencing consortium NCBI37/mm9 assembly), corresponding sequences from human, chicken, frog, coelacanth, pufferfish, medaka, stickleback, zebrafish and elephant shark were aligned. Alignment shows regions of homology between tetrapod, coelacanth and ray-finned fishes. b, Alignment of vertebrate cis-regulatory elements I1, I2, I3, I4, CsB and CsC. c, Expression patterns of coelacanth island I in a transgenic mouse. Limb buds are indicated by arrowheads in the first two panels. The third panel shows a close-up of a limb bud.

Expression Data

Expression Detail

Antibody Labeling

Phenotype Data

Phenotype Detail

Acknowledgments

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