FIGURE

Fig. S15

ID

ZDB-FIG-130418-16

Publication

Amemiya et al., 2013 - The African coelacanth genome provides insights into tetrapod evolution

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Fig. S15

Schematic representation of the hepatic urea cycle. In the mitochondrion the toxic ammonium (NH4+) is coupled with carbondioxide (CO2)and phosphate from ATP to produce carbamoyl phosphate. This is the rate limiting step of the cycle and is catalyzed by the enzyme carbamoyl phosphate synthase 1 (CPS1). The carbamoylphosphate is then transferred to ornithine by ornithine-carbamoylphosphate transferase, leaves the mitochondrion and is further metabolised in two steps by argininosuccinate synthase 1 (ASS1) and argininosuccinatelyse (ASL) to finally generate the aminoacid arginine. By arginase 2 (ARG2) urea is released and ornithine is recovered, which then enters the mitochondrion to initiate a new round of the cycle.

Expression Data

Expression Detail

Antibody Labeling

Phenotype Data

Phenotype Detail

Acknowledgments

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