FIGURE

Fig. 5

ID

ZDB-FIG-121116-36

Publication

Mackenzie et al., 2012 - Proliferative regeneration of zebrafish lateral line hair cells after different ototoxic insults

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Fig. 5

Flubendazole impairs division of hair cell progenitors.

ET4:GFP larvae were treated at 5 dpf with neomycin or copper for 1 h and incubated in flubendazole for 24 h. Immunohistochemistry was performed for GFP and PHH3, which is upregulated during mitosis. (A) Two-way ANOVA followed by Bonferroni post-hoc analysis found significant increases in the proportion of PHH3-positive cells in neomycin- and copper-treated larvae when treated with flubendazole (*, p<0.05; ***, p<0.001), demonstrating that cell division was arrested in GFP-positive hair cell precursors. N = 8 fish per group. Error bars are + SD. (B) Example neuromast at 24 hpt from a fish treated with neomycin and flubendazole. Arrows mark PHH3-positive nuclei.

Expression Data

Expression Detail

Antibody Labeling

Phenotype Data

Phenotype Detail

Acknowledgments

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