FIGURE

Fig. 3

ID

ZDB-FIG-121116-35

Publication

Mackenzie et al., 2012 - Proliferative regeneration of zebrafish lateral line hair cells after different ototoxic insults

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Fig. 3

Hair cells are derived from proliferating progenitors.

(A) Wild type larvae were treated at 5 dpf with neomycin or copper for 1 h followed by recovery in 5 mM BrdU until 24 hpt followed by fresh embryo medium. Greater numbers of BrdU-positive hair cells were observed in all ototoxin-treated groups at 72 hpt. (B) One-way ANOVA followed by a Tukey post-hoc analysis of the proportion of BrdU-positive hair cells revealed significant increases in all ototoxin-treated groups compared to control (p<0.001). No significant difference was observed between 1 and 10 μM copper that would suggest a dose-dependent effect on proliferative regeneration. A small but significant difference was observed between neomycin and 1 μM copper (*, p<0.05). N = 8 fish per group. Error bars are + SD. (C) Example neuromast at 72 hpt from a fish treated with 1 μM copper. Arrows mark BrdU-positive hair cells.

Expression Data

Expression Detail

Antibody Labeling

Phenotype Data

Phenotype Detail

Acknowledgments

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