FIGURE

Fig. 4

ID

ZDB-FIG-120604-3

Publication

Poulain et al., 2002 - Mezzo, a paired-like homeobox protein is an immediate target of Nodal signalling and regulates endoderm specification in zebrafish

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Fig. 4

Analyses of mezzo expression in various mutants of the Nodal signalling pathway. All the embryos were fixed at the shield stage except those in B,H (40% epiboly). (A-F) Side views, (G-L) animal pole views. (A,G) Control wild-type embryos. Expression of mezzo was lost on the dorsal side in Zoep (B,H) and squint (C,I) mutant embryos. Expression of mezzo was abolished in cyc;sqt double mutants (D,J) and variably affected in MZsur embryos. The variable expression of mezzo in MZsur correlated with the expressivity of the schmalspur phenotype. The embryos shown in E,K derived from a cross producing severely affected embryos. Expression of mezzo is greatly diminished in two thirds of the marginal region in bon;faust double mutants (F,L).

Expression Data

Gene:	sebox
Fish:	AB foxh1^m768/m768 ndr1^cz35/cz35 tdgf1^m134/m134 gata5^{tm236a/tm236a}; mixl1^m425/m425 ndr1^cz35/cz35; Df(Chr12:hhex,ndr2)b16/b16
Anatomical Terms:	margin margin ventral side
Stage Range:	30%-epiboly to Shield

Expression Detail

Antibody Labeling

Phenotype Data

Phenotype Detail

Acknowledgments

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