Gene
sebox
- ID
- ZDB-GENE-021206-4
- Name
- SEBOX homeobox
- Symbol
- sebox Nomenclature History
- Previous Names
- Type
- protein_coding_gene
- Location
- Chr: 5 Mapping Details/Browsers
- Description
- Predicted to enable DNA-binding transcription factor activity, RNA polymerase II-specific and RNA polymerase II transcription regulatory region sequence-specific DNA binding activity. Acts upstream of or within endoderm development; heart morphogenesis; and regulation of DNA-templated transcription. Predicted to be located in nucleus. Is expressed in margin; marginal blastomere; presumptive endoderm; and shield. Orthologous to human SEBOX (SEBOX homeobox).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 16 figures from 12 publications
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
- No data available
Wild Type Expression Summary
- All Phenotype Data
- No data available
- Cross-Species Comparison
- Alliance
Phenotype Summary
Mutations
| Allele | Type | Localization | Consequence | Mutagen | Supplier |
|---|---|---|---|---|---|
| sa33769 | Allele with one point mutation | Unknown | Splice Site | ENU |
1 - 1 of 1
Show
| Targeting Reagent | Created Alleles | Citations |
|---|---|---|
| CRISPR1-sebox | Prummel et al., 2019 | |
| MO1-sebox | N/A | (3) |
1 - 2 of 2
Show
Human Disease
Domain, Family, and Site Summary
Domain Details Per Protein
| Protein | Additional Resources | Length | Homedomain-like superfamily | Homeobox protein SEBOX | Homeodomain |
|---|---|---|---|---|---|
| UniProtKB:Q8JJ26 | InterPro | 293 | |||
| UniProtKB:A0AB32TU47 | InterPro | 333 |
Interactions and Pathways
No data available
Plasmids
No data available
| Construct | Regulatory Region | Coding Sequence | Species | Tg Lines | Citations |
|---|---|---|---|---|---|
| Tg(sebox:EGFP) |
|
| 1 | (8) |
1 - 1 of 1
Show
| Relationship | Marker Type | Marker | Accession Numbers | Citations |
|---|---|---|---|---|
| Contained in | BAC | CH211-110P13 | ZFIN Curated Data |
1 - 1 of 1
Show
| Type | Accession # | Sequence | Length (nt/aa) | Analysis |
|---|---|---|---|---|
| RNA | RefSeq:NM_001320052 (1) | 4523 nt | ||
| Genomic | GenBank:BX957226 (2) | 149414 nt | ||
| Polypeptide | UniProtKB:A0AB32TU47 (1) | 333 aa |
- Wang, B., Rong, X., Zhou, Y., Liu, Y., Sun, J., Zhao, B., Deng, B., Lu, L., Lu, L., Li, Y., Zhou, J. (2021) Eukaryotic initiation factor 4A3 inhibits Wnt/β-catenin signaling and regulates axis formation in zebrafish embryos. Development (Cambridge, England). 148(9):
- Prummel, K.D., Hess, C., Nieuwenhuize, S., Parker, H.J., Rogers, K.W., Kozmikova, I., Racioppi, C., Brombacher, E.C., Czarkwiani, A., Knapp, D., Burger, S., Chiavacci, E., Shah, G., Burger, A., Huisken, J., Yun, M.H., Christiaen, L., Kozmik, Z., Müller, P., Bronner, M., Krumlauf, R., Mosimann, C. (2019) A conserved regulatory program initiates lateral plate mesoderm emergence across chordates. Nature communications. 10:3857
- Vopalensky, P., Pralow, S., Vastenhouw, N.L. (2018) Reduced expression of the Nodal coreceptor Oep causes loss of mesendodermal competence in zebrafish. Development (Cambridge, England). 145(5)
- Chen, G., Tan, R.B., Tao, Q.H. (2015) Sebox regulates mesoderm formation in early amphibian embryos. Developmental Dynamics : an official publication of the American Association of Anatomists. 244(11):1415-26
- Ruprecht, V., Wieser, S., Callan-Jones, A., Smutny, M., Morita, H., Sako, K., Barone, V., Ritsch-Marte, M., Sixt, M., Voituriez, R., Heisenberg, C.P. (2015) Cortical Contractility Triggers a Stochastic Switch to Fast Amoeboid Cell Motility. Cell. 160:673-685
- Satija, R., Farrell, J.A., Gennert, D., Schier, A.F., Regev, A. (2015) Spatial reconstruction of single-cell gene expression data. Nat. Biotechnol.. 33(5):495-502
- Fontenille, L., Rouquier, S., Lutfalla, G., Giorgi, D. (2014) Microtubule-associated protein 9 (Map9/Asap) is required for the early steps of zebrafish development. Cell cycle (Georgetown, Tex.). 13(7):1101-14
- Du, S., Draper, B.W., Mione, M., Moens, C.B., and Bruce, A.E. (2012) Differential regulation of epiboly initiation and progression by zebrafish Eomesodermin A. Developmental Biology. 362(1):11-23
- Pereira, L.A., Wong, M.S., Mei Lim, S., Stanley, E.G., and Elefanty, A.G. (2012) The Mix family of homeobox genes - key regulators of mesendoderm formation during vertebrate development. Developmental Biology. 367(2):163-177
- Tseng, W.F., Jang, T.H., Huang, C.B., and Yuh, C.H. (2011) An evolutionarily conserved kernel of gata5, gata6, otx2 and prdm1a operates in the formation of endoderm in zebrafish. Developmental Biology. 357(2):541-57
1 - 10 of 22
Show