FIGURE

Fig. 2

ID

ZDB-FIG-120525-18

Publication

Telfer et al., 2012 - neb: a zebrafish model of nemaline myopathy due to nebulin mutation

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Fig. 2

neb embryos are morphologically abnormal and have disrupted birefringence. Live imaging of neb embryos and age-matched littermates (CTL) at 3 dpf (A) and 4 dpf (B). Compared with controls, neb zebrafish are smaller, have thin and bent tails, and have pericardial edema. The heart structure is not obviously abnormal (arrows and see supplementary material Movies 3, 4). (C) Live image analysis of 3 dpf embryos using polarized light to detect birefringence. Wild type (CTL) embryos have normal birefringence, whereas neb embryos have diminished and patchy birefringence. The pattern is variable between neb embryos. Depicted for comparison is an age-matched sapje (sap) embryo. sap zebrafish have a recessive mutation in dystrophin and abnormal birefringence.

Expression Data

Expression Detail

Antibody Labeling

Phenotype Data

Fish:	dmd^tj7/tj7 neb^{hu2849/hu2849} (AB)
Observed In:	heart contraction muscle muscle sarcomere pericardium post-vent region whole organism
Stage Range:	Protruding-mouth to Day 4

Phenotype Detail

Acknowledgments

This image is the copyrighted work of the attributed author or publisher, and ZFIN has permission only to display this image to its users. Additional permissions should be obtained from the applicable author or publisher of the image. Full text @ Dis. Model. Mech.