FIGURE

Fig. 4

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ZDB-FIG-120511-41

Publication

Sun et al., 2012 - Zebrafish chemical screening reveals the impairment of dopaminergic neuronal survival by cardiac glycosides

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Fig. 4

Neriifolin-induced DA neuronal death is apoptotic and requires p53.

(A?D′ ′′) Low (A?D) and high (A′?D′ ′′) magnification views of VFB DA neurons in control (A-A′ ′′) vs Neriifolin-treated embryos (B-B′ ′′), and sympathetic (Sym) NA neurons in control (C-C′ ′′) vs Neriifolin-treated embryos (D-D′ ′′). Ventral views of 60 hpf embryos were shown. Neriifolin treatment was carried out from 24 hpf to 60 hpf. (E) Injection of the p53-MO into embryos at one-cell stage protected DA neurons from cell death induced by Neriifolin. Data are the averages ± SEM from 6 embryos in a single experiment that was repeated twice with similar results.

Expression Data

Expression Detail

Antibody Labeling

Phenotype Data

Phenotype Detail

Acknowledgments

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