FIGURE

Fig. 2

ID

ZDB-FIG-120511-40

Publication

Sun et al., 2012 - Zebrafish chemical screening reveals the impairment of dopaminergic neuronal survival by cardiac glycosides

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Fig. 2

Human atp1a3 rescues DA neurons in Neriifolin-treated embryos.

(A) The expression pattern of atp1a3a in wild-type embryos at 48 hpf. (B) The schematic diagram of the plasmid constructs used for the rescue experiments in zebrafish embryos. (C) RT-PCR detection of the expression of human atp1a3 in zebrafish embryos after injection and heat shock. (D?E) Quantification (D) and representative images (E) of VFB DA neurons in 5 μM Neriifolin-treated embryos that express either GFP or human atp1a3. Data are the averages ± SEM from 9 embryos in a single experiment that was repeated twice with similar results.

Expression Data

Expression Detail

Antibody Labeling

Phenotype Data

Phenotype Detail

Acknowledgments

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