FIGURE

Fig. 2

ID

ZDB-FIG-120508-9

Publication

Stewart et al., 2012 - Limited dedifferentiation provides replacement tissue during zebrafish fin regeneration

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Fig. 2

Newly regenerated epidermis is derived from pre-existing epidermal cells. (A–D, A*–D*) Whole mount epifluorescent images from the caudal fin from a Tg(dusp6:Cre-ERT2, EAB:EGFP-FlEx-mCherry) animal containing Class 1 labeled epidermal cells before amputation (A, A*), 1 dpa (B, B*), 4 dpa (C, C*), and 14 dpa (D, D*). Dashed boxes marked with an asterisk represent the region shown at higher magnification in the panel directly below. (A–D) and (A*–D*) are images acquired at 25 × and 120 × magnifications, respectively. EGFP⁺ cells are in green and mCherry⁺ cells are pseudocolored magenta. The top and bottom of each panel correspond to the distal and proximal regions of the fin, respectively. The dashed yellow line shows the approximate amputation site and the white arrows point to epidermal cells found laterally to the starting population.

Expression Data

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Antibody Labeling

Phenotype Data

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Acknowledgments

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Reprinted from Developmental Biology, 365(2), Stewart, S., and Stankunas, K., Limited dedifferentiation provides replacement tissue during zebrafish fin regeneration, 339-349, Copyright (2012) with permission from Elsevier. Full text @ Dev. Biol.