FIGURE

Fig. 1

ID

ZDB-FIG-120201-39

Publication

Tao et al., 2011 - Zebrafish prox1b Mutants Develop a Lymphatic Vasculature, and prox1b Does Not Specifically Mark Lymphatic Endothelial Cells

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Fig. 1

Prox1b is expressed in the endothelial cells and the central nervous system of the head.

(A–C) shows prox1b transcript expression by whole mount in situ hybridization in wild-type embryos, at 12 hpf. Black arrows point to prox1b expression in the head; red arrows indicate prox1b expression in lateral plate mesoderm. Confocal image (D) shows YFP expression in a prox1b BAC:YFP embryo at 19 hpf stage. (E) and (F) show YFP expression, enhanced by DAB immunostaining, is detected in prox1b BAC:YFP embryos in migrating angioblasts at 15 hpf. (G–I) shows prox1b:YFP expression in the head region of a prox1b BAC:YFP, fli1:DsRed embryo. Note overlapping (endothelial cells) and non-overlapping expression domains. (J) shows prox1b:YFP expression in the trunk vasculature. (K) shows enlarged view of the boxed area in (J). Scale bars represent 50 μm in (K), and 100 μm in other figures.

Expression Data

Genes:	Citrine DsRedx prox3
Fish:	WT hu7009Tg hu7009Tg; um13Tg
Anatomical Terms:	dorsal aorta endothelial cell head central nervous system intermediate cell mass of mesoderm intersegmental vessel lateral plate mesoderm posterior cardinal vein
Stage Range:	5-9 somites to Prim-15

Expression Detail

Antibody Labeling

Phenotype Data

Phenotype Detail

Acknowledgments

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