ZFIN ID: ZDB-FIG-111215-47
Li et al., 2011 - Abca12-mediated lipid transport and Snap29-dependent trafficking of lamellar granules are crucial for epidermal morphogenesis in a zebrafish model of ichthyosis. Disease models & mechanisms   4(6):777-85 Full text @ Dis. Model. Mech.
ADDITIONAL FIGURES
PHENOTYPE:
Fish:
Knockdown Reagents:
Observed In:
Stage: Protruding-mouth

Fig. 5 SEM of the skin surface. The skin of the tail of the control larvae injected with the global standard control morpholino at 3 dpf shows the presence of keratinocytes with well-demarcated cell-cell borders (arrowhead) containing microridges (star; left panel). The morphant larvae injected with MO1 morpholino for abca12 (middle) or snap29 (MO2; right panel) revealed perturbed microridge formation with spicules in the center of the keratinocytes.

Gene Expression Details No data available
Antibody Labeling Details No data available
Phenotype Details
Fish Conditions Stage Phenotype
WT + MO1-abca12 standard conditions Protruding-mouth epidermis morphogenesis disrupted, abnormal
Protruding-mouth epidermis morphology, abnormal
Protruding-mouth keratinocyte cell surface disorganized, abnormal
WT + MO1-snap29 standard conditions Protruding-mouth epidermis morphogenesis disrupted, abnormal
Protruding-mouth epidermis morphology, abnormal
Protruding-mouth keratinocyte cell surface disorganized, abnormal
Acknowledgments:
ZFIN wishes to thank the journal Disease models & mechanisms for permission to reproduce figures from this article. Please note that this material may be protected by copyright. Full text @ Dis. Model. Mech.