FIGURE

Fig. 1

ID

ZDB-FIG-111101-3

Publication

Andoniadou et al., 2011 - HESX1- and TCF3-mediated repression of Wnt/β-catenin targets is required for normal development of the anterior forebrain

Other Figures

Fig. 1

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Fig. 1

hesx1 and hdl (tcf3a) genetically interact for proper anterior-posterior patterning of the zebrafish brain. Lateral views of 2 day post-fertilisation zebrafish embryos. (A,B) Untreated embryos of hdl^+/? control (A) and hdl^?/? (B) genotypes, both showing normal forebrain development. (C,D) Injection with zebrafish hesx1 MO at the one-cell stage to knockdown Hesx1 results in anterior defects in hdl^?/? embryos (arrowhead in D), which are sensitised to increased levels of Wnt signalling. Injection of hesx1 MO into control hdl^+/? embryos has no effect (C). (E,F) Anterior defects generated by hesx1 MO injection are rescued by co-injection of murine Hesx1 mRNA (F). Injection of Hesx1 mRNA alone has no effect (E).

Expression Data

Expression Detail

Antibody Labeling

Phenotype Data

Fish:	tcf7l1a^m881/+ + MO1-hesx1 tcf7l1a^m881/m881 + MO1-hesx1
Knockdown Reagent:	MO1-hesx1
Observed In:	diencephalon eye forebrain development telencephalon whole organism
Stage:	Long-pec

Phenotype Detail

Acknowledgments

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