FIGURE SUMMARY
Title

HESX1- and TCF3-mediated repression of Wnt/β-catenin targets is required for normal development of the anterior forebrain

Authors
Andoniadou, C.L., Signore, M., Young, R.M., Gaston-Massuet, C., Wilson, S.W., Fuchs, E., and Martinez-Barbera, J.P.
Source
Full text @ Development
Fig. 1

hesx1 and hdl (tcf3a) genetically interact for proper anterior-posterior patterning of the zebrafish brain. Lateral views of 2 day post-fertilisation zebrafish embryos. (A,B) Untreated embryos of hdl+/? control (A) and hdl?/? (B) genotypes, both showing normal forebrain development. (C,D) Injection with zebrafish hesx1 MO at the one-cell stage to knockdown Hesx1 results in anterior defects in hdl?/? embryos (arrowhead in D), which are sensitised to increased levels of Wnt signalling. Injection of hesx1 MO into control hdl+/? embryos has no effect (C). (E,F) Anterior defects generated by hesx1 MO injection are rescued by co-injection of murine Hesx1 mRNA (F). Injection of Hesx1 mRNA alone has no effect (E).
Acknowledgments
This image is the copyrighted work of the attributed author or publisher, and ZFIN has permission only to display this image to its users. Additional permissions should be obtained from the applicable author or publisher of the image. Full text @ Development
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