ZFIN Image: Andoniadou et al., 2011, Fig. 1

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Figure Caption

Fig. 1

hesx1 and hdl (tcf3a) genetically interact for proper anterior-posterior patterning of the zebrafish brain. Lateral views of 2 day post-fertilisation zebrafish embryos. (A,B) Untreated embryos of hdl^+/? control (A) and hdl^?/? (B) genotypes, both showing normal forebrain development. (C,D) Injection with zebrafish hesx1 MO at the one-cell stage to knockdown Hesx1 results in anterior defects in hdl^?/? embryos (arrowhead in D), which are sensitised to increased levels of Wnt signalling. Injection of hesx1 MO into control hdl^+/? embryos has no effect (C). (E,F) Anterior defects generated by hesx1 MO injection are rescued by co-injection of murine Hesx1 mRNA (F). Injection of Hesx1 mRNA alone has no effect (E).

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Acknowledgments

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