FIGURE

Fig. S2

ID

ZDB-FIG-111025-17

Publication

Perlin et al., 2011 - Neuronal Neuregulin 1 type III directs Schwann cell migration

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Fig. S2

Early and late Schwann cell markers are absent in nrg1^z26 mutants. (A,B) Dorsal views of nrg1 type III mRNA expression in nrg1^z26/+ (A) and nrg1^z26 (n=3/3) embryos at 35 hpf. Arrow marks PLLg. (C,D) sox10 marks Schwann cells along the PLLn (arrowheads) in a wild-type embryo (C), but is almost absent along the PLLn of an nrg1^z26 mutant (n=11/11) (D). (E-H) Myelin basic protein mRNA (E) and protein (G) is expressed along the PLLn (arrowheads) of wild-type embryos, but not in nrg1^z26 mutants (F, n=3/3; H, n=6/6). Scale bar: 50 μm.

Expression Data

Genes:	mbpa nrg1 sox10
Fish:	WT nrg1^z26/z26 nrg1^z26/+
Anatomical Terms:	posterior lateral line ganglion posterior lateral line nerve myelinating Schwann cell
Stage Range:	Prim-15 to Day 6

Expression Detail

Antibody Labeling

Phenotype Data

Fish:	nrg1^z26/z26
Observed In:	myelinating Schwann cell peripheral nervous system myelin formation posterior lateral line nerve
Stage Range:	Protruding-mouth to Day 6

Phenotype Detail

Acknowledgments

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