FIGURE

Fig. 1

ID

ZDB-FIG-111017-15

Publication

Lenhart et al., 2011 - Two additional midline barriers function with midline lefty1 expression to maintain asymmetric Nodal signaling during left-right axis specification in zebrafish

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Fig. 1

spaw and lefty1 expression phenotypes. (A-F′′)Time course of single color, double in situ hybridizations for spaw and lefty1 from 10-18 somites in posterior (A-F), mid-LPM (A′-F′), left lateral (A′-F′) and anterior LPM (A′′-F′′) views. (A-A′′) False-colored images of zebrafish embryos from B-B′′ depicting the domains of spaw and lefty1. In situ hybridizations of spaw or lefty1 alone confirm the reported phenotypes. Arrows, boundary of detectable spaw expression; brackets, ectopic spaw across the midline; arrowheads, lefty1 in the diencephalon; asterisks, lefty1 in the cardiac mesoderm. L, left; R, right.

Expression Data

Genes:	lft1 spaw
Fish:	WT acvr1l^{tm110b/tm110b} bmp4^b1172/b1172 WT + MO1-lft1 WT + MO1-lft2
Knockdown Reagents:	MO1-lft1 MO1-lft2
Anatomical Terms:	diencephalon left side diencephalon right side heart primordium Kupffer's vesicle anatomical region Kupffer's vesicle left side Kupffer's vesicle right side lateral plate mesoderm lateral plate mesoderm left side notochord notochord posterior region posterior lateral plate mesoderm left side posterior lateral plate mesoderm posterior side posterior lateral plate mesoderm right side
Stage Range:	10-13 somites to 14-19 somites

Expression Detail

Antibody Labeling

Phenotype Data

Fish:	WT + MO1-lft2
Knockdown Reagent:	MO1-lft2
Observed In:	heart primordium left side heart primordium right side
Stage:	14-19 somites

Phenotype Detail

Acknowledgments

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