FIGURE

Fig. 1

ID

ZDB-FIG-110817-11

Publication

Neumann et al., 2011 - Mutation in the type IB bone morphogenetic protein receptor alk6b impairs germ-cell differentiation and causes germ-cell tumors in zebrafish

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Fig. 1

The tgct mutants develop GCTs because of impaired germ-cell differentiation. Compared with adult wild-type males (A and C) (arrowhead: normal testis), adult tgct males display marked testicular enlargement (B and D) (arrow: testicular tumor). Wild-type testis (E) exhibits normal spermatogenesis (arrowhead: spermatogonia; arrow: spermatozoa). The tgct mutant testis (F) accumulates primitive germ cells. Although wild-type ovary (G) shows all stages of oocyte maturation up to mature stage IV oocytes, oocyte maturation is impaired in tgct homozygous females (H). [Scale bars: 100 μm (E and F); 50 μm (G and H).]

Expression Data

Expression Detail

Antibody Labeling

Phenotype Data

Fish:	bmpr1bb^sw40/sw40
Observed In:	female organism germ cell development oocyte maturation oocyte stage IV primordial germ cell testis testis germ cell tumor (all 7)
Stage:	Adult

Phenotype Detail

Acknowledgments

This image is the copyrighted work of the attributed author or publisher, and ZFIN has permission only to display this image to its users. Additional permissions should be obtained from the applicable author or publisher of the image. Full text @ Proc. Natl. Acad. Sci. USA