FIGURE

Fig. 4

ID

ZDB-FIG-110712-91

Publication

Ren et al., 2011 - Disruption of LRRK2 Does Not Cause Specific Loss of Dopaminergic Neurons in Zebrafish

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Fig. 4

RNA whole mount in situ hybridization of 3 dpf embryos with th probe didn′t show significant loss of DA neurons in LRRK2 morphants.

A to D, the diencephalon region of zebrafish embryos, dorsal view, anterior to the top. The numbers on bottom right corner showed number of the embryos with a certain phenotype/number of total embryos in that group. There was not obvious alteration of DA neurons pattern in the diencephalon of the morphants (B, C, and D). E, quantative result of th positive neurons in the diencephalon. There was not significant DA neurons loss in all three morphant groups. n = 20 in each group, P>>0.05 in all comparisons.

Expression Data

Gene:	th
Fish:	AB AB + MO1-lrrk2 + MO2-lrrk2 AB + MO4-lrrk2 AB + MO5-lrrk2
Knockdown Reagents:	MO1-lrrk2 MO2-lrrk2 MO4-lrrk2 MO5-lrrk2
Anatomical Term:	diencephalon dopaminergic neuron
Stage:	Protruding-mouth

Expression Detail

Antibody Labeling

Phenotype Data

Phenotype Detail

Acknowledgments

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