Morpholino

MO1-lrrk2

ID
ZDB-MRPHLNO-100520-4
Name
MO1-lrrk2
Previous Names
  • MO51EI (1)
Target
Sequence
5' - CACAAGCAGATTTATTAACCTGTGC - 3'
ZFIN BLAST NCBI BLAST Ensembl UCSC BLAT
Disclaimer
Although ZFIN verifies reagent sequence data, we recommend that you conduct independent sequence analysis before ordering any reagent.
Note
splice-blocking MO targeted to intron 45 splice donor junction, designed to delete exon 45, introducing a premature stop codon in the WD40 domain.
Genome Resources
None
Target Location
Genome Build: GRCz11Chromosome: 25
Genomic Features
No data available
Expression
Gene expression in Wild Types + MO1-lrrk2
No data available
Phenotype
Phenotype resulting from MO1-lrrk2
No data available
Phenotype of all Fish created by or utilizing MO1-lrrk2
Phenotype Fish Conditions Figures
embryo development delayed, abnormal AB + MO1-lrrk2 + MO2-lrrk2 standard conditions Fig. Table 1 from Ren et al., 2011
diencephalon dopaminergic neuron irregular spatial pattern, abnormal AB + MO1-lrrk2 + MO2-lrrk2 standard conditions Fig. 3 with image from Ren et al., 2011
optic tectum neuron decreased amount, abnormal WT + MO1-lrrk2 + MO2-lrrk2 standard conditions Fig. 4 with image from Sheng et al., 2010
neuron apoptotic process increased occurrence, abnormal WT + MO1-lrrk2 + MO2-lrrk2 standard conditions Fig. 3 with image from Sheng et al., 2010
optic tectum axon decreased amount, abnormal WT + MO1-lrrk2 + MO2-lrrk2 standard conditions Fig. 4 with image from Sheng et al., 2010
diencephalon dopaminergic neuron decreased amount, abnormal WT + MO1-lrrk2 + MO2-lrrk2 standard conditions Fig. 3 with image,  Fig. 5 with image from Sheng et al., 2010
locomotion decreased occurrence, abnormal WT + MO1-lrrk2 + MO2-lrrk2 standard conditions Fig. 6 with image from Sheng et al., 2010
midbrain neuron decreased amount, abnormal kca2Tg; rk8Tg + MO1-lrrk2 + MO2-lrrk2 standard conditions Fig. 3 with image from Sheng et al., 2010
Citations
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