FIGURE

Fig. 3

ID

ZDB-FIG-110214-15

Publication

Tittle et al., 2011 - Uhrf1 and Dnmt1 are required for development and maintenance of the zebrafish lens

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Fig. 3

dnmt1 mutants also possess abnormal lenses and cataracts. (A) Wild-type and (B) dnmt1 mutant embryos at 5 dpf. Mutants display obvious lens defects and in the more severely affected embryos lens dysplasias are observed (arrow in B). F-actin staining of wild-type (A′) and mild dnmt1 (B′) eye cryosections show that the anterior region of dnmt1 mutant lenses contain many disorganized nucleated cells that do not resemble the cuboidal structure of the wild-type lens epithelial monolayer. (C–F) Transverse histology from (C,E) wild-type and (D,F) dnmt1 mutant embryos at (C,D) 5 dpf and (E,F) 7 dpf. Mutants display lens dysplasias, peripheral fiber unraveling from the core of differentiated fibers and lens degeneration. Scale bars are 80 μm.

Expression Data

Expression Detail

Antibody Labeling

Phenotype Data

Fish:	dnmt1^s872/s872
Observed In:	lens lens epithelium
Stage Range:	Day 5 to Days 7-13

Phenotype Detail

Acknowledgments

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Reprinted from Developmental Biology, 350(1), Tittle, R.K., Sze, R., Ng, A., Nuckels, R.J., Swartz, M.E., Anderson, R.M., Bosch, J., Stainier, D.Y., Eberhart, J.K., and Gross, J.M., Uhrf1 and Dnmt1 are required for development and maintenance of the zebrafish lens, 50-63, Copyright (2011) with permission from Elsevier. Full text @ Dev. Biol.