FIGURE

Fig. 1

ID
ZDB-FIG-110112-7
Publication
Danilova et al., 2010 - p53 Upregulation Is a Frequent Response to Deficiency of Cell-Essential Genes
Other Figures
All Figure Page
Back to All Figure Page
Fig. 1

Phenotype of mutants for housekeeping genes are similar and depend on p53 network upregulation.

A–C) Excessive neural apoptosis was manifested as gray areas in the brain at 24 hpf, which was rescued by p53 inhibition D–F) At 48 hpf, there were more apoptotic cells in mutants compared to siblings and p53 inhibition led to a decrease in apoptosis. Acridine orange staining. G–I) There were fewer erythroid cells in mutants compared to siblings, which was rescued by p53 inhibition. o-dianizidine staining, 84 hpf, arrow points to erythrocytes. K–L) tp53 upregulation was higher in the brain and blood cells, 48 hpf, in situ hybridization, arrow points to erythrocytes.
Expression Data
Gene:
Fish:
Anatomical Terms:
Stage: Long-pec

Expression Detail
Antibody Labeling
Phenotype Data
Fish:
Knockdown Reagent:
Observed In:
Stage Range: Prim-5 to Protruding-mouth

Phenotype Detail
Acknowledgments
This image is the copyrighted work of the attributed author or publisher, and ZFIN has permission only to display this image to its users. Additional permissions should be obtained from the applicable author or publisher of the image. Full text @ PLoS One
Your Input Welcome
We welcome your input and comments. Please use this form to recommend updates to the information in ZFIN. We appreciate as much detail as possible and references as appropriate. We will review your comments promptly.
Please check the highlighted fields and try again.
Thank you for submitting comments. Your input has been emailed to ZFIN curators who may contact you if additional information is required.
Oops. Something went wrong. Please try again later.