FIGURE

Fig. 7

ID

ZDB-FIG-101206-49

Publication

Choy et al., 2010 - A cascade of irx1a and irx2a controls shh expression during retinogenesis

Other Figures

All Figure Page

Back to All Figure Page

Fig. 7

Spread of the waves of shh-GFP expression is rescued by overexpression of irx2a in irx1a morphants. In control shh-GFP transgenic embryos (A–D), shh-GFP is expressed in the ventronasal side of the control retina (A). This expression spreads to the central retina at about 38 hpf (B), and then to the entire GCL and INL from about 42 to 48 hpf (C and D). The expression of shh-GFP is initiated in the irx1a MO2 morphant retina (E) but with a delay of about 8 hr (E–H). Furthermore, shh-GFP is not expressed in the central and dorsal regions of the irx1a morphant retina (G,H). Similar to control embryos, the shh-GFP waves propagated normally in the retina of irx1a morphants co-injected with irx2a mRNA (I–L).

Expression Data

Gene:	GFP
Fish:	sb28Tg sb28Tg + MO4-irx1a
Knockdown Reagent:	MO4-irx1a
Anatomical Terms:	retina retinal ganglion cell layer retinal inner nuclear layer
Stage Range:	Prim-15 to Long-pec

Expression Detail

Antibody Labeling

Phenotype Data

Fish:	sb28Tg + MO4-irx1a
Knockdown Reagent:	MO4-irx1a
Observed In:	neural retina development retina layer formation retinal ganglion cell layer retinal inner nuclear layer
Stage Range:	Prim-15 to Long-pec

Phenotype Detail

Acknowledgments

This image is the copyrighted work of the attributed author or publisher, and ZFIN has permission only to display this image to its users. Additional permissions should be obtained from the applicable author or publisher of the image. Full text @ Dev. Dyn.