FIGURE

Fig. 9

ID

ZDB-FIG-101025-23

Publication

Wong et al., 2010 - Duplicate dmbx1 genes regulate progenitor cell cycle and differentiation during zebrafish midbrain and retinal development

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Fig. 9

Figure 9. Rescue of the midbrain and retinal phenotype in morphants is species-specific. The expression domain of foxb1.2 in un-injected 48 hpf embryos (A) and rho in un-injected 72 hpf embryos (E) is significantly reduced in the MO1a injected embryos (B, F). Co-injection of zebrafish dmbx1a significantly rescues these phenotypes (C, G), whereas co-injection of mouse Dmbx1 mRNA does not (D, H). Arrow in A-D demarcates the region of the rostrolateral hindbrain (where the EG is located) at 48 hpf. For A-D, images represent dorsal views, anterior to the top. For E-H, images represent ventral views, anterior to the top. MO, morpholino; hpf, hours post-fertilization. Asterisk in (C) demonstrates ectopic foxb1.2 expression, which was commonly observed in embryos over-expressed with zebrafish dmbx1a, but not mouse Dmbx1 mRNA.

Expression Data

Expression Detail

Antibody Labeling

Phenotype Data

Phenotype Detail

Acknowledgments

This image is the copyrighted work of the attributed author or publisher, and ZFIN has permission only to display this image to its users. Additional permissions should be obtained from the applicable author or publisher of the image. Full text @ BMC Dev. Biol.