|ZFIN ID: ZDB-FIG-100628-13|
|Stage Range:||5-9 somites to 14-19 somites|
Fig. 1 Activity of mouse Looptail VANGL1 mutant RNAs in zebrafish lacking tri. Panels A–E show lateral views of zebrafish at 2 days post fertilization. In Panel A, an uninjected wild-type fish is shown. In Panel B, a fish injected with tri-MO alone show a marked shortening of the trunk. In Panel C, VANGL1 RNA partially rescued the trunk phenotype induced by co-injection of tri-MO. Co-injection of VANGL1D259E (Panel D) or VANGL1S467N (Panel E) with tri-MO did not rescue the reduced body length phenotype induced by tri-MO.
|myod1||WT||control||5-9 somites to 14-19 somites||somite||ISH|
|WT + MO1-vangl2||standard conditions||5-9 somites to 14-19 somites||somite||ISH|
|WT + MO1-vangl2||standard conditions||Long-pec||trunk decreased length, abnormal|
|Long-pec||whole organism anterior-posterior axis decreased length, abnormal|
ZFIN wishes to thank the journal Mechanisms of Development for permission to reproduce figures from this article.
Please note that this material may be protected by copyright.
Reprinted from Mechanisms of Development, 127(7-8), Reynolds, A., McDearmid, J.R., Lachance, S., Marco, P.D., Merello, E., Capra, V., Gros, P., Drapeau, P., and Kibar, Z., VANGL1 rare variants associated with neural tube defects affect convergent extension in zebrafish, 385-392, Copyright (2010) with permission from Elsevier. Full text @ Mech. Dev.