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Fig. 1 Activity of mouse Looptail VANGL1 mutant RNAs in zebrafish lacking tri. Panels A–E show lateral views of zebrafish at 2 days post fertilization. In Panel A, an uninjected wild-type fish is shown. In Panel B, a fish injected with tri-MO alone show a marked shortening of the trunk. In Panel C, VANGL1 RNA partially rescued the trunk phenotype induced by co-injection of tri-MO. Co-injection of VANGL1D259E (Panel D) or VANGL1S467N (Panel E) with tri-MO did not rescue the reduced body length phenotype induced by tri-MO.
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Reprinted from Mechanisms of Development, 127(7-8), Reynolds, A., McDearmid, J.R., Lachance, S., Marco, P.D., Merello, E., Capra, V., Gros, P., Drapeau, P., and Kibar, Z., VANGL1 rare variants associated with neural tube defects affect convergent extension in zebrafish, 385-392, Copyright (2010) with permission from Elsevier. Full text @ Mech. Dev.