FIGURE

Fig. 4

ID

ZDB-FIG-100429-101

Publication

Das et al., 2010 - A forward chemical screen in zebrafish identifies a retinoic acid derivative with receptor specificity

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Fig. 4

BT10 causes specific cardiovascular defects when added at 24 hpf.

Shown are representative embryos (from 3 experiments, for each sample n = 20) that were cultured between 24–60 hpf in the presence of DMSO alone (A, control) or BT10 (B). Note the defined morphological structure of the ventral yolk sac (arrow). A normal looping heart tube fails to develop in these embryos. Panels C and D show higher magnification views of representative control (C) and BT10-treated (D) embryos, respectively. The red block arrow indicates blood flowing through the normal control heart, which is not evident in the BT10-treated embryos. Views are lateral, anterior to the right, dorsal at the top.

Expression Data

Expression Detail

Antibody Labeling

Phenotype Data

Fish:	WT
Condition:	chemical treatment: pharmaceutical
Observed In:	heart
Stage:	Pec-fin

Phenotype Detail

Acknowledgments

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