Fig. S3
Notch inhibition reduces biliary secretion. A-D: Fluorescence microscopy images (lateral view) of live 6-dpf larvae (144 hpf) following ingestion of the fluorescent lipid bodipy-C16. In wild types (wt), strong fluorescence is detected in the intestine (i) and gallbladder (g). Fluorescence emission from both tissues is reduced in larvae treated with DAPT between 50-120 hpf. Each panel shows a unique larva. These data are representative of 10 wild type and 10 DAPT-treated larvae. |