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ZFIN ID: ZDB-FIG-091116-14
Mullins et al., 1996 - Genes establishing dorsoventral pattern formation in the zebrafish embryo: the ventral specifying genes. Development (Cambridge, England)   123:81-93
ADDITIONAL FIGURES
PHENOTYPE:
Fish:
Observed In:
Stage Range: 75%-epiboly to 14-19 somites

Fig. 1

Morphological defects visible in live mutant gastrulae of swr, snh and pgy. Dorsal is to the right in lateral views and animal pole is up in dorsal views. (A-D) Wild type, (E-H) swr (class 5 phenotype), (I-K) snh (class 4 phenotype), (L-N) pg (class 3 phenotype). A lateral view of an 80% epiboly stage wild-type (A) and swr mutant (E) embryo showing the thickened ventral side (white arrowhead) and thinner dorsal axis (black arrowhead) in swr. A dorsal view at bud stage of wild-type (B), swr (F), snh (I), and pgy (L) embryos (the notochord is delineated by arrowheads). Dorsal views of 4- somite stage embryos: wild-type (C), swr (G), snh (J), and pgy (M). The most lateral extent of the somites is marked by arrowheads; an arrow indicates the position of the tailbud, which is not visible in the wild type (C) because it has extended around the yolk. (D,H,K,N) Lateral views of 14-somite stage embryos: wild-type (D), swr (H), snh (K), and pgy (N) (the tailbud is indicated with an arrow).

Gene Expression Details No data available
Antibody Labeling Details No data available
Phenotype Details
Fish Conditions Stage Phenotype
bmp2bta72a/ta72a(TU) standard conditions 75%-epiboly axis thickness, abnormal
75%-epiboly gastrulation with mouth forming second disrupted, abnormal
Bud gastrulation with mouth forming second disrupted, abnormal
Bud notochord increased width, abnormal
1-4 somites somite fused with somite, abnormal
1-4 somites somite increased width, abnormal
1-4 somites tail bud mislocalised posteriorly, abnormal
1-4 somites whole organism ovate, abnormal
Bud whole organism ovate, abnormal
14-19 somites whole organism lethal (sensu genetics), abnormal
14-19 somites yolk broken, abnormal
bmp7aty68a/ty68a standard conditions Bud gastrulation with mouth forming second disrupted, abnormal
Bud notochord increased width, abnormal
1-4 somites somite increased width, abnormal
1-4 somites tail bud mislocalised posteriorly, abnormal
1-4 somites whole organism ovate, abnormal
Bud whole organism ovate, abnormal
14-19 somites trunk rotational curvature, abnormal
smad5dty40/dty40(TU) standard conditions 1-4 somites somite increased width, abnormal
1-4 somites tail bud increased size, abnormal
Bud tail bud protruding, abnormal
14-19 somites tail bud increased size, abnormal
14-19 somites tail bud mislocalised, abnormal
Acknowledgments:
ZFIN wishes to thank the journal Development (Cambridge, England) for permission to reproduce figures from this article. Please note that this material may be protected by copyright.