FIGURE

Fig. 8

ID

ZDB-FIG-090804-49

Publication

Drerup et al., 2009 - Disc1 regulates foxd3 and sox10 expression, affecting neural crest migration and differentiation

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Fig. 8

Peripheral cranial glia populations were expanded in Disc1 morphants. (A-F) foxd3 expression, which marks the developing glia, was expanded at 48 hpf and 51 hpf, but not 40 hpf, in Disc1 morphants (arrowheads indicate enhanced expression in the trigeminal ganglion and the posterior lateral line ganglion). (G,H) Glial expansion was suppressed by SMO2 co-injection. (I-K) Glial expansion was also suppressed in 49% of Disc1 morphants from a sox10^m241/+ by wild-type cross. Uninjected embryos (I; n=47) showed normal foxd3 expression, whereas Disc1 morphants (n=144) showed two distinct phenotypes, expanded (J, arrowheads) and normal (K) foxd3 expression, which probably correlates to their genotype (wild-type or heterozygous). (L) Table showing the percentage of Disc1 morphants with glial expansion (left) and suppression of expansion by SMO2 co-injection (right).

Expression Data

Gene:	foxd3
Fish:	WT WT + MO3-disc1 WT + MO3-sox10 sox10^m241/+ sox10^m241/+ + MO3-disc1 WT + MO3-disc1 + MO3-sox10
Knockdown Reagents:	MO3-disc1 MO3-sox10
Anatomical Terms:	posterior lateral line ganglion glial cell trigeminal ganglion glial cell
Stage Range:	Prim-25 to Long-pec

Expression Detail

Antibody Labeling

Phenotype Data

Fish:	WT + MO3-disc1
Knockdown Reagent:	MO3-disc1
Observed In:	posterior lateral line ganglion glial cell trigeminal ganglion glial cell
Stage:	Long-pec

Phenotype Detail

Acknowledgments

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