FIGURE

Fig. 6

ID

ZDB-FIG-090306-44

Publication

Matthews et al., 2009 - TNF{alpha}-dependent hepatic steatosis and liver degeneration caused by mutation of zebrafish s-adenosylhomocysteine hydrolase

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Fig. 6

Liver steatosis, increased lipogenic gene expression, and methionine metabolism defects in adult dtp heterozygotes. (A,B) SAM and SAH levels from livers of (A) adult fish treated with deazaA and (B) adult dtp heterozygotes, as compared with wild-type (wt) controls. (C,D) Liver histology from adult wild-type and heterozygous dtp fish showing vesicular clearing consistent with steatosis. (E,F) Oil Red O staining of adult wild-type and heterozygous dtp fish reveals steatosis in the heterozygotes. Lipid is evident in wild-type liver sinusoids (E, arrows), but not in hepatocytes. (G-I) Elevated expression of tnfa (G), pparg (H) and the ROS-sensitive gene thioredoxin reductase (trx) (I), in the liver of adult dtp heterozygous versus wild-type fish. ^*P=0.05, ^**P<0.05, ^***P<0.005.

Expression Data

Expression Detail

Antibody Labeling

Phenotype Data

Phenotype Detail

Acknowledgments

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