FIGURE

Fig. 5

ID

ZDB-FIG-090306-43

Publication

Matthews et al., 2009 - TNF{alpha}-dependent hepatic steatosis and liver degeneration caused by mutation of zebrafish s-adenosylhomocysteine hydrolase

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Fig. 5

Ahcy inhibition in adult zebrafish causes liver steatosis and activates tnfa expression. (A) Quantitative real-time PCR reveals elevated tnfa expression in adult zebrafish liver following 7-day treatment with the Ahcy inhibitor 3-deaza-adenosine (deazaA). (B,C) Oil Red O staining reveals steatosis in deazaA-treated adult livers, as compared with control. (D) Reduced liver mitochondrial glutathione (GSH) in deazaA-treated adult fish compared with control. ^*P<0.05, ^**P<0.005; error bars indicate s.e.m.

Expression Data

Expression Detail

Antibody Labeling

Phenotype Data

Phenotype Detail

Acknowledgments

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