FIGURE

Fig. 2

ID

ZDB-FIG-090113-22

Publication

Matsuda et al., 2009 - Interaction with Notch determines endocytosis of specific Delta ligands in zebrafish neural tissue

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Fig. 2

Accumulation of DeltaD protein on the plasma membrane in the mib mutant. (A,B) Hindbrain expression of deltaD transcript in wild-type (WT) and mib^ta52b 10-somite stage (10 ss) zebrafish embryos. (C,D) DeltaD protein in areas corresponding to the rectangles in A and B. Embryos are stained with zdD2. The patches of DeltaD expression in D are in rhombomeres 3, 4 and 5. (E,F) deltaD transcript in wild type and mib^ta52b at the tail bud stage (tb) in hindbrain neurogenic domains. Area shown here corresponds approximately to rectangular areas in Fig. S1A,B (see supplementary material). mib^ta52b embryos do not have significantly exaggerated deltaD expression. (G,H) zdD2 staining in corresponding wild-type and mib^ta52b neurogenic domains. In mib^ta52b mutants, most DeltaD is at the cell surface, even when expression is not so exaggerated.

Expression Data

Gene:	dld
Antibody:	Ab1-dld
Fish:	WT mib1^m178/m178 mib1^ta52b/ta52b
Anatomical Terms:	hindbrain hindbrain cytoplasm hindbrain neural plate hindbrain neural plate cell surface hindbrain neural plate cytoplasm rhombomere 3 rhombomere 4 rhombomere 5
Stage Range:	Bud to 10-13 somites

Expression Detail

Antibody Labeling

Phenotype Data

Phenotype Detail

Acknowledgments

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