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General Information
ZFIN ID: ZDB-FIG-081203-1
Anichtchik et al., 2008 - Loss of PINK1 function affects development and results in neurodegeneration in zebrafish. The Journal of neuroscience : the official journal of the Society for Neuroscience   28(33):8199-8207 Full text @ J. Neurosci.
Knockdown Reagents:
Anatomical Terms:
Stage Range: 256-cell to Adult
Knockdown Reagents:
Observed In:
Stage Range: Prim-5 to Long-pec

Fig. 1 ZFIN is incorporating published figure images and captions as part of an ongoing project. Figures from some publications have not yet been curated, or are not available for display because of copyright restrictions.

Gene Expression Details
Gene Antibody Fish Conditions Stage Anatomy Assay
pink1 Ab1-pink1 AB control Prim-5 whole organism WB
AB standard conditions 256-cell to Shield whole organism RTPCR
Prim-5 whole organism ISH
Prim-5 to Protruding-mouth whole organism RTPCR
Long-pec muscle ISH
Long-pec nervous system ISH
Day 6 whole organism RTPCR
Ab1-pink1 Adult caudal tuberculum IHC
Ab1-pink1 Adult hypothalamus IHC
Ab1-pink1 Adult optic tectum IHC
Ab1-pink1 Adult third ventricle IHC
Ab1-pink1 AB + MO1-pink1 + MO2-pink1 standard conditions Prim-5 whole organism WB
Antibody Labeling Details
Antibody Assay Fish Conditions Stage Anatomy
Ab1-th IHC AB standard conditions Adult hypothalamus
IHC Adult optic tectum
IHC Adult third ventricle
Phenotype Details
Fish Conditions Stage Phenotype
AB + MO1-pink1 + MO2-pink1 standard conditions Prim-5 eye decreased size, abnormal
Prim-5 head low brightness, abnormal
Prim-5 head morphology, abnormal
Prim-5 head opaque, abnormal
Prim-5 head development arrested, abnormal
Prim-5 post-anal tail morphogenesis arrested, abnormal
Prim-5 post-vent region curved ventral, abnormal
Prim-5 post-vent region decreased length, abnormal
Prim-5 somite shape, abnormal
Long-pec brain increased size, abnormal
Long-pec caudal fin shape, abnormal
Long-pec extension decreased width, abnormal
Long-pec head decreased size, abnormal
Long-pec head low brightness, abnormal
Long-pec head opaque, abnormal
Long-pec pericardium edematous, abnormal
Long-pec sensory perception of touch arrested, abnormal
Long-pec spinal cord curved ventral, abnormal
Full text @ J. Neurosci.