Gene
pink1
- ID
- ZDB-GENE-041212-53
- Name
- PTEN induced kinase 1
- Symbol
- pink1 Nomenclature History
- Previous Names
-
- wu:fc39e12
- zgc:101729 (1)
- Type
- protein_coding_gene
- Location
- Chr: 23 Mapping Details/Browsers
- Description
- Predicted to have protein serine/threonine kinase activity. Involved in several processes, including dopaminergic neuron differentiation; nucleate erythrocyte development; and regulation of vascular endothelial growth factor signaling pathway. Localizes to cytosol and mitochondrion. Used to study Parkinson's disease and early-onset Parkinson's disease. Human ortholog(s) of this gene implicated in Parkinson's disease and Parkinson's disease 6. Is expressed in several structures, including digestive system; gill; heart; nervous system; and spleen. Orthologous to human PINK1 (PTEN induced kinase 1).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 27 figures from 18 publications
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
-
- MGC:101729 (1 image)
Wild Type Expression Summary
- All Phenotype Data
- 40 figures from 13 publications
- Cross-Species Comparison
- Alliance
Phenotype Summary
Mutations
Human Disease
| Disease Ontology Term | Multi-Species Data | OMIM Term | OMIM Phenotype ID |
|---|---|---|---|
| Parkinson's disease 6 | Alliance | Parkinson disease 6, early onset | 605909 |
Domain, Family, and Site Summary
Domain Details Per Protein
| Protein | Length | PINK1, protein kinase domain | Protein kinase domain | Protein kinase-like domain superfamily | Serine/threonine-protein kinase, active site |
|---|---|---|---|---|---|
|
UniProtKB:Q5PRB2
|
574 |
- Genome Browsers
Interactions and Pathways
No data available
| Name | Type | Antigen Genes | Isotype | Host Organism | Assay | Source | Citations |
|---|---|---|---|---|---|---|---|
| Ab1-pink1 | polyclonal | IgG | Rabbit |
|
Cayman Chemical Company
|
7 |
Plasmids
No data available