Gene

pink1

ID

ZDB-GENE-041212-53

Name

PTEN induced kinase 1

Symbol

pink1 Nomenclature History

Previous Names

wu:fc39e12
zgc:101729 (1)

Type

protein_coding_gene

Location

Chr: 23 Mapping Details/Browsers

Description

Predicted to enable protein serine/threonine kinase activity. Acts upstream of or within several processes, including dopaminergic neuron differentiation; nucleate erythrocyte development; and swimming behavior. Located in cytosol and mitochondrion. Is expressed in several structures, including digestive system; gill; heart; nervous system; and spleen. Used to study Parkinson's disease and early-onset Parkinson's disease. Human ortholog(s) of this gene implicated in Parkinson's disease and Parkinson's disease 6. Orthologous to human PINK1 (PTEN induced kinase 1).

Genome Resources

Note

None

Comparative Information

Expression

All Expression Data

28 figures from 19 publications

Cross-Species Comparison

High Throughput Data

Expression Atlas

UO scRNA-seq (UCSC browser)

Single Cell Expression Atlas

Daniocell

Thisse Expression Data

MGC:101729 (1 image)

Wild Type Expression Summary

Phenotype

All Phenotype Data: 40 figures from 13 publications
Cross-Species Comparison: Alliance

Phenotype Summary

Mutations

Mutants

Sequence Targeting Reagents

Human Disease

Associated With pink1 Human Ortholog

Disease Ontology Term	Multi-Species Data	OMIM Term	OMIM Phenotype ID
Parkinson's disease 6	Alliance	Parkinson disease 6, early onset	605909

Associated With pink1 Via Experimental Models

Human Disease	Fish	Conditions	Citations
Parkinson's disease	AB + MO1-pink1 + MO2-pink1	standard conditions	Anichtchik et al., 2008
Parkinson's disease	pink1^{zf1035/zf1035}	standard conditions	Matsui et al., 2017
Parkinson's disease	pink1^sh397/sh397 (AB)	standard conditions	Soman et al., 2019
early-onset Parkinson's disease	pink1^sh397/sh397	standard conditions	Soman et al., 2017

Gene Ontology

Protein Domains

Domain, Family, and Site Summary

Type	InterPro ID	Name
Active_site	IPR008271	Serine/threonine-protein kinase, active site
Domain	IPR000719	Protein kinase domain
Domain	IPR040110	PINK1, protein kinase domain
Family	IPR051511	Mitochondrial Quality Control and Scaffold Kinases
Homologous_superfamily	IPR011009	Protein kinase-like domain superfamily

Domain Details Per Protein

Protein	Length	Mitochondrial Quality Control and Scaffold Kinases	PINK1, protein kinase domain	Protein kinase domain	Protein kinase-like domain superfamily	Serine/threonine-protein kinase, active site
UniProtKB:Q5PRB2 InterPro	574

Transcripts

Genome Browsers

NCBI

Type	Name	Annotation Method	Has Havana Data	Length (nt)	Analysis
mRNA	pink1-201 (1) Ensembl	Ensembl		4,010 nt	Select Tool ZFIN BLAST

Interactions and Pathways

No data available

Antibodies

Name	Type	Antigen Genes	Isotype	Host Organism	Assay	Source	Citations
Ab1-pink1	polyclonal	pink1	IgG	Rabbit	IHC WB	Cayman Chemical Company	7

Plasmids

Constructs

Marker Relationships

Sequences

Orthology

Comparative Orthology: Alliance
Gene Tree: Ensembl

Citations