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ZIRC
ZFIN ID: ZDB-GENE-041212-53
Gene Name: PTEN induced kinase 1
Gene Symbol: pink1    Nomenclature History

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Previous Names: wu:fc39e12, zgc:101729 (1)

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(Including Attributions)
Gene Type: protein_coding_gene
Location: Chr: 23 Mapping Details/Browsers
Description: Predicted to have protein serine/threonine kinase activity. Involved in several processes, including dopaminergic neuron differentiation; nucleate erythrocyte development; and regulation of vascular endothelial growth factor signaling pathway. Localizes to the cytosol and mitochondrion. Used to study Parkinson's disease and early-onset Parkinson's disease. Human ortholog(s) of this gene implicated in Parkinson's disease and Parkinson's disease 6. Is expressed in several structures, including digestive system; gill; heart; nervous system; and spleen. Orthologous to human PINK1 (PTEN induced kinase 1).
Genome Resources: Alliance (1),  Gene:494085 (1),  Ensembl(GRCz11):ENSDARG00000001929 (2)
MUTATIONS AND SEQUENCE TARGETING REAGENTS
Allele Type Localization Consequence Mutagen Suppliers
gi2 Small Deletion Unknown Premature Stop TALEN
ihb272 Insertion Exon 2 Unknown CRISPR
ihb273 Small Deletion Exon 2 Unknown CRISPR
sh397 Point Mutation Unknown Unknown ENU
zf1035 Small Deletion Unknown Unknown CRISPR
Sequence Targeting Reagents
Targeting Reagent Created Alleles Publications
CRISPR1-pink1 1
CRISPR2-pink1 1
MO1-pink1 N/A 3
MO2-pink1 N/A 2
MO3-pink1 N/A 1
MO4-pink1 N/A 2
MO5-pink1 N/A 3
MO6-pink1 N/A 1
MO7-pink1 N/A 1
TALEN1-pink1 1
DISEASE ASSOCIATED WITH pink1 HUMAN ORTHOLOG
Disease Ontology Term Multi-Species Data OMIM Term OMIM Phenotype ID
Parkinson's disease 6 Alliance Parkinson disease 6, early onset 605909
GENE ONTOLOGY
Ontology GO Term
Biological Process autophagy of mitochondrion (more)
Cellular Component cytosol (more)
Molecular Function ATP binding (more)
GO Terms (all 19)
TRANSCRIPTS No data available
INTERACTIONS AND PATHWAYS
ANTIBODIES
Name Type Isotype Host Organism Assay Source Publications
Ab1-pink1 polyclonal IgG Rabbit IHC, WB Cayman Chemical Company
6
PLASMIDS No data available
CONSTRUCTS WITH SEQUENCES FROM pink1
Construct Regulatory Regions Coding Sequences Species Tg Lines Publications
Tg(pink1:EGFP) pink1 EGFP Danio rerio 1 3
MARKER RELATIONSHIPS
pink1 Encodes: [EST] fc39e12
[cDNA] MGC:101729 (1) (order this), MGC:175012 (1) (order this), MGC:192855 (1) (order this)
SEQUENCE INFORMATION
Type Accession # Length (bp/aa) Analysis
RNA RefSeq:NM_001008628 (1) 2088 bp
Polypeptide UniProtKB:B5DFT6 (1) 574 aa
Sequence Clusters UniGene:78644 (1)
Sequence Information (all 21)
ORTHOLOGY for pink1 ( Chr: 23 )
CITATIONS (41)