Gene

pink1

ID
ZDB-GENE-041212-53
Name
PTEN induced kinase 1
Symbol
pink1 Nomenclature History
Previous Names
  • wu:fc39e12
  • zgc:101729 (1)
Type
protein_coding_gene
Location
Chr: 23 Mapping Details/Browsers
Description
Predicted to have protein serine/threonine kinase activity. Involved in several processes, including dopaminergic neuron differentiation; nucleate erythrocyte development; and regulation of vascular endothelial growth factor signaling pathway. Localizes to cytosol and mitochondrion. Used to study Parkinson's disease and early-onset Parkinson's disease. Human ortholog(s) of this gene implicated in Parkinson's disease and Parkinson's disease 6. Is expressed in several structures, including digestive system; gill; heart; nervous system; and spleen. Orthologous to human PINK1 (PTEN induced kinase 1).
Genome Resources
Note
None
Comparative Information
Expression
All Expression Data
23 figures from 14 publications
Cross-Species Comparison
High Throughput Data
Thisse Expression Data
Wild Type Expression Summary
Phenotype
All Phenotype Data
38 figures from 12 publications
Cross-Species Comparison
Alliance
Phenotype Summary
Mutations
Mutants
Sequence Targeting Reagents
Human Disease
Associated With pink1 Human Ortholog
Disease Ontology Term Multi-Species Data OMIM Term OMIM Phenotype ID
Parkinson's disease 6 Alliance Parkinson disease 6, early onset 605909
Associated With pink1 Via Experimental Models
Gene Ontology
Protein Domains
Domain, Family, and Site Summary
Type InterPro ID Name
Active_site IPR008271 Serine/threonine-protein kinase, active site
Domain IPR000719 Protein kinase domain
Domain IPR040110 PINK1, protein kinase domain
Homologous_superfamily IPR011009 Protein kinase-like domain superfamily
Domain Details Per Protein
Protein Length PINK1, protein kinase domain Protein kinase domain Protein kinase-like domain superfamily Serine/threonine-protein kinase, active site
UniProtKB:Q5PRB2 574
UniProtKB:B5TXD9 574
UniProtKB:B5DFT6 574
UniProtKB:F1QTR3 574
Transcripts
Genome Browsers
No data available
Interactions and Pathways
No data available
Antibodies
Name Type Antigen Genes Isotype Host Organism Assay Source Citations
Ab1-pink1 polyclonal IgG Rabbit
  • IHC
  • WB
Cayman Chemical Company
6
Plasmids
No data available
Constructs
Marker Relationships
Sequences
Orthology
Comparative Orthology
Alliance
Gene Tree
Ensembl
Citations