Gene

pink1

ID
ZDB-GENE-041212-53
Name
PTEN induced kinase 1
Symbol
pink1 Nomenclature History
Previous Names
  • wu:fc39e12
  • zgc:101729 (1)
Type
protein_coding_gene
Location
Chr: 23 Mapping Details/Browsers
Description
Predicted to have protein serine/threonine kinase activity. Involved in several processes, including dopaminergic neuron differentiation; nucleate erythrocyte development; and regulation of vascular endothelial growth factor signaling pathway. Localizes to cytosol and mitochondrion. Is expressed in several structures, including digestive system; gill; heart; nervous system; and spleen. Used to study Parkinson's disease and early-onset Parkinson's disease. Human ortholog(s) of this gene implicated in Parkinson's disease and Parkinson's disease 6. Orthologous to human PINK1 (PTEN induced kinase 1).
Genome Resources
Note
None
Expression
All Expression Data
19 figures from 10 publications
Cross-Species Comparison
High Throughput Data
No data available
Wild Type Expression Summary
Phenotype
All Phenotype Data
36 figures from 11 publications
Cross-Species Comparison
Alliance
Phenotype Summary
Mutations
Mutants
Sequence Targeting Reagents
Human Disease
Associated With pink1 Human Ortholog
Disease Ontology Term Multi-Species Data OMIM Term OMIM Phenotype ID
Parkinson's disease 6 Alliance Parkinson disease 6, early onset 605909
Associated With pink1 Via Experimental Models
Gene Ontology
Protein Domains
Domain, Family, and Site Summary
Type InterPro ID Name
Active_site IPR008271 Serine/threonine-protein kinase, active site
Domain IPR000719 Protein kinase domain
Domain IPR040110 PINK1, protein kinase domain
Homologous_superfamily IPR011009 Protein kinase-like domain superfamily
Domain Details Per Protein
Protein Length PINK1, protein kinase domain Protein kinase domain Protein kinase-like domain superfamily Serine/threonine-protein kinase, active site
UniProtKB:F1QTR3 574
UniProtKB:B5TXD9 574
UniProtKB:B5DFT6 574
UniProtKB:Q5PRB2 574
Transcripts
Genome Browsers
No data available
Interactions and Pathways
No data available
Antibodies
Name Type Antigen Genes Isotype Host Organism Assay Source Citations
Ab1-pink1 polyclonal IgG Rabbit
  • IHC
  • WB
Cayman Chemical Company
6
Plasmids
No data available
Constructs
Marker Relationships
Sequences
Orthology
Ensembl Gene Tree
Citations