Gene

pink1

ID

ZDB-GENE-041212-53

Name

PTEN induced kinase 1

Symbol

pink1 Nomenclature History

Previous Names

wu:fc39e12
zgc:101729 (1)

Type

protein_coding_gene

Location

Chr: 23 Mapping Details/Browsers

Description

Predicted to have protein serine/threonine kinase activity. Involved in several processes, including dopaminergic neuron differentiation; nucleate erythrocyte development; and regulation of vascular endothelial growth factor signaling pathway. Localizes to cytosol and mitochondrion. Used to study Parkinson's disease and early-onset Parkinson's disease. Human ortholog(s) of this gene implicated in Parkinson's disease and Parkinson's disease 6. Is expressed in several structures, including digestive system; gill; heart; nervous system; and spleen. Orthologous to human PINK1 (PTEN induced kinase 1).

Genome Resources

Note

None

Comparative Information

Expression

All Expression Data

28 figures from 19 publications

Cross-Species Comparison

High Throughput Data

Expression Atlas

UO scRNA-seq (UCSC browser)

Single Cell Expression Atlas

Daniocell

Thisse Expression Data

MGC:101729 (1 image)

Wild Type Expression Summary

Phenotype

All Phenotype Data: 40 figures from 13 publications
Cross-Species Comparison: Alliance

Phenotype Summary

Mutations

Mutants

Sequence Targeting Reagents

Human Disease

Associated With pink1 Human Ortholog

Disease Ontology Term	Multi-Species Data	OMIM Term	OMIM Phenotype ID
Parkinson's disease 6	Alliance	Parkinson disease 6, early onset	605909

Associated With pink1 Via Experimental Models

Human Disease	Fish	Conditions	Citations
Parkinson's disease	AB + MO1-pink1 + MO2-pink1	standard conditions	Anichtchik et al., 2008
Parkinson's disease	pink1^{zf1035/zf1035}	standard conditions	Matsui et al., 2017
Parkinson's disease	pink1^sh397/sh397 (AB)	standard conditions	Soman et al., 2019
early-onset Parkinson's disease	pink1^sh397/sh397	standard conditions	Soman et al., 2017

Gene Ontology

Protein Domains

Domain, Family, and Site Summary

Type	InterPro ID	Name
Active_site	IPR008271	Serine/threonine-protein kinase, active site
Domain	IPR000719	Protein kinase domain
Domain	IPR040110	PINK1, protein kinase domain
Family	IPR051511	Mitochondrial Quality Control and Scaffold Kinases
Homologous_superfamily	IPR011009	Protein kinase-like domain superfamily

Domain Details Per Protein

Protein	Length	Mitochondrial Quality Control and Scaffold Kinases	PINK1, protein kinase domain	Protein kinase domain	Protein kinase-like domain superfamily	Serine/threonine-protein kinase, active site
UniProtKB:Q5PRB2 InterPro	574

Transcripts

Genome Browsers

NCBI

Type	Name	Annotation Method	Has Havana Data	Length (nt)	Analysis
mRNA	pink1-201 (1) Ensembl	Ensembl		4,010 nt	Select Tool ZFIN BLAST

Interactions and Pathways

No data available

Antibodies

Name	Type	Antigen Genes	Isotype	Host Organism	Assay	Source	Citations
Ab1-pink1	polyclonal	pink1	IgG	Rabbit	IHC WB	Cayman Chemical Company	7

Plasmids

Constructs

Marker Relationships

Sequences

Orthology

Comparative Orthology: Alliance
Gene Tree: Ensembl

Citations