FIGURE
Fig. 1
- ID
- ZDB-FIG-081013-44
- Publication
- Lele et al., 1999 - Disruption of zebrafish somite development by pharmacologic inhibition of hsp90
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Fig. 1
Specific interaction of zebrafish Hsp90 with solid-phase geldanamycin (GA). Using Western blot analysis with anti-Hsp90 antibody, Hsp90 was detected to bind to GA-derivatized resin (B, lane 1) and this interaction was completely inhibited by preincubation with free GA prior to application to the GA resin (lane 2). Zebrafish Hsp90 comigrated with rabbit reticulocyte lysate Hsp90 detected using the same antibody (lane 3). No other proteins interacted with the resin in a specific manner as determined by silver staining of SDS–polyacrylamide gels (compare lanes 1 and 2 of A). |
Expression Data
Expression Detail
Antibody Labeling
Phenotype Data
Phenotype Detail
Acknowledgments
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Reprinted from Developmental Biology, 210(1), Lele, Z., Hartson, S.D., Martin, C.C., Whitesell, L., Matts, R.L., and Krone, P.H., Disruption of zebrafish somite development by pharmacologic inhibition of hsp90, 56-70, Copyright (1999) with permission from Elsevier. Full text @ Dev. Biol.