FIGURE

Fig. S5

ID

ZDB-FIG-080828-29

Publication

Goessling et al., 2008 - APC mutant zebrafish uncover a changing temporal requirement for wnt signaling in liver development

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Fig. S5

APC loss affects endodermal fate. (A–C) Insulin and (D–F) trypsin in situ hybridization at 72 hpf in all APC genotypes revealed a decrease in endocrine and exocrine pancreas size in both APC^+/^- (insulin: 51/65; trypsin: 68/74) and APC^-/- (insulin: 25/29; trypsin: 32/32) mutants. The dimensions of the endocrine pancreas in wild-type embryos are indicated with black bars for comparison. An arrowhead highlights a small area of trypsin expression in one homozygous mutant embryo. (G-I) ifabp expression is affected in a similar manner to that seen with lfabp; APC^+/^- embryos had an increase in ifabp (31/55), while there was an absence of expression in homozygous mutants (28/29). The (^) indicates the presence of minimal ifabp expression found in a single embryo.

Expression Data

Genes:	fabp2 ins prss1
Fish:	WT apc^hu745/hu745 apc^hu745/+
Anatomical Terms:	endocrine pancreas exocrine pancreas intestine
Stage:	Protruding-mouth

Expression Detail

Antibody Labeling

Phenotype Data

Fish:	apc^hu745/hu745 apc^hu745/+
Observed In:	digestive tract development pancreas pancreas development
Stage:	Protruding-mouth

Phenotype Detail

Acknowledgments

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Reprinted from Developmental Biology, 320(1), Goessling, W., North, T.E., Lord, A.M., Ceol, C., Lee, S., Weidinger, G., Bourque, C., Strijbosch, R., Haramis, A.P., Puder, M., Clevers, H., Moon, R.T., and Zon, L.I., APC mutant zebrafish uncover a changing temporal requirement for wnt signaling in liver development, 161-174, Copyright (2008) with permission from Elsevier. Full text @ Dev. Biol.